Blar i forfatter "Falck, Aleksander Tank"

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    • The Ambivalence of Connexin43 Gap Peptides in Cardioprotection of the Isolated Heart against Ischemic Injury 

      Falck, Aleksander Tank; Lund, Bjarte Aarmo; Johansen, David; Lund, trine; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-05)
      The present study investigates infarct-reducing effects of blocking ischemia-induced opening of connexin43 hemichannels using peptides Gap19, Gap26 or Gap27. Cardioprotection by ischemic preconditioning (IPC) and Gap peptides was compared, and combined treatment was tested in isolated, perfused male rat hearts using function and infarct size after global ischemia, high-resolution respirometry of ...

    • Human concentrations of uric acid scavenges adaptive and maladaptive ROS in isolated rat hearts subjected to ischemic stress 

      Boardman, Neoma Tove; Falck, Aleksander Tank; Lund, Trine; Chu, X; Martin, Armas Maria Montserrat; Norvik, Jon Viljar; Jenssen, Trond Geir; Ytrehus, Kirsti (Journal article; Tidsskriftartikkel; Peer reviewed, 2019-09-14)
      Uric acid is a purine degradation product but also an important antioxidant and ROS scavenger. Experimental settings that mimic myocardial ischemia-reperfusion have not included uric acid despite that it is always present in human extracellular fluid and plasma. We hypothesized that uric acid has an important role in myocardial ROS scavenging. Here, we tested the cardiac response to uric acid on ...